Abstract
Replying to F.-J. Müller & A. Schuppert Nature 478, 10.1038/nature10543 (2011)
Müller and Schuppert1 describe an exception to our finding2 that roughly 80% of the nodes must be controlled to gain full control over gene regulatory networks. Yet our result hides subtleties that reveal as much about controllability as about the limits of our current understanding of biological networks.
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References
Müller, F.-J. & Schuppert, A. Few inputs can reprogram biological networks. Nature 478, 10.1038/nature10543 (this issue).
Liu, Y.-Y., Slotine, J.-J. & Barabási, A.-L. Controllability of complex networks. Nature 473, 167–173 (2011)
Li, F., Long, T., Lu, Y., Ouyang, Q. & Tang, C. The yeast cell-cycle network is robustly designed. Proc. Natl Acad. Sci. USA 101, 4781–4786 (2004)
Waddington, C. H. The Strategy of the Genes (Geo Allen & Unwin, 1957)
Huang, S., Eichler, G., Bar-Yam, Y. & Ingber, D. Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys. Rev. Lett. 94, 1–4 (2005)
Venkatesan, K. et al. An empirical framework for binary interactome mapping. Nature Methods 6, 83–90 (2009)
Barabási, A.-L., Gulbahce, N. & Loscalzo, J. Network medicine: a network-based approach to human disease. Nature Rev. Genet. 12, 56–68 (2011)
Slotine, J.-J. & Li, W. Applied Nonlinear Control (Prentice-Hall, 1991)
Isidori, A. Nonlinear Control Systems (Springer, 1995)
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All authors designed and did the research. Y.-Y.L. analysed the empirical data and did the analytical and numerical calculations. A.-L.B. was the lead writer of the manuscript.
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Liu, YY., Slotine, JJ. & Barabási, AL. Liu et al. reply. Nature 478, E4–E5 (2011). https://doi.org/10.1038/nature10544
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DOI: https://doi.org/10.1038/nature10544
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