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Structural biology

Peering into the spark of life

Nature volume 475, pages 305–306 (2011)Cite this article

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Sodium channels in cell membranes have a crucial role in triggering bioelectrical events that lead to processes such as muscle contraction or hormone release. A crystal structure reveals how one such channel might work. See Article p.353

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Figure 1: Bird's-eye view of a voltage-gated ion channel.

R. HORN

References

  1. Hille, B. Ion Channels of Excitable Membranes 3rd edn (Sinauer, 2001).

    Google Scholar 

  2. Payandeh, J., Scheuer, T., Zheng, N. & Catterall, W. A. Nature 475, 353–358 (2011).

    Article  CAS  Google Scholar 

  3. Bezanilla, F. & Stefani, E. Annu. Rev. Biophys. Biomol. Struct. 23, 819–846 (1994).

    Article  CAS  Google Scholar 

  4. Catterall, W. A. Novartis Found. Symp. 241, 206–218 (2002).

    CAS  PubMed  Google Scholar 

  5. Hirschberg, B., Rovner, A., Lieberman, M. & Patlak, J. J. Gen. Physiol. 106, 1053–1068 (1995).

    Article  CAS  Google Scholar 

  6. Long, S. B., Campbell, E. B. & MacKinnon, R. Science 309, 903–908 (2005).

    Article  ADS  CAS  Google Scholar 

  7. Long, S. B. et al. Nature 450, 376–382 (2007).

    Article  ADS  CAS  Google Scholar 

  8. Shin, K. S., Maertens, C., Proenza, C., Rothberg, B. S. & Yellen, G. Neuron 41, 737–744 (2004).

    Article  CAS  Google Scholar 

  9. Clayton, G. M. et al. Proc. Natl Acad. Sci. USA 105, 1511–1515 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Catterall, W. A. Annu. Rev. Biochem. 55, 953–985 (1986).

    Article  CAS  Google Scholar 

  11. Guy, H. R. & Seetharamulu, P. Proc. Natl Acad. Sci. USA 83, 508–512 (1986).

    Article  ADS  CAS  Google Scholar 

  12. Eisenman, G. Biophys. J. 2, 259–323 (1962).

    Article  ADS  CAS  Google Scholar 

  13. Cuello, L. G. et al. Nature 466, 272–275 (2010).

    Article  ADS  CAS  Google Scholar 

  14. Fozzard, H. A., Lee, P. J. & Lipkind, G. M. Curr. Pharm. Des. 11, 2671–2686 (2005).

    Article  CAS  Google Scholar 

Download references

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  1. Richard Horn is in the Department of Molecular Physiology and Biophysics, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.,

    Richard Horn

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  1. Richard Horn
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Correspondence to Richard Horn.

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Horn, R. Peering into the spark of life. Nature 475, 305–306 (2011). https://doi.org/10.1038/475305a

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