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HIV

Going for the watchman

Nature volume 474, pages 587–588 (2011)Cite this article

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A protein called SAMHD1 seems to hinder the infection of key cells of the immune system by HIV-1. Cousins of this virus, however, produce a factor that overcomes the protective effects of SAMHD1. See Letters p.654 & p.658

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Figure 1: Vpx, SAMHD1 and viral replication1,2.

References

  1. Laguette, N. et al. Nature 474, 654–657 (2011).

    Article  CAS  Google Scholar 

  2. Hrecka, K. et al. Nature 474, 658–661 (2011).

    Article  CAS  Google Scholar 

  3. Srivastava, S. et al. PLoS Pathog. 4, e1000059 (2008).

    Article  Google Scholar 

  4. Bergamaschi, A. et al. J. Virol. 83, 4854–4860 (2009).

    Article  CAS  Google Scholar 

  5. Goujon, C. et al. Retrovirology 4, 2 (2007).

    Article  Google Scholar 

  6. Rice, G. I. et al. Nature Genet. 41, 829–832 (2009).

    Article  CAS  Google Scholar 

  7. Stetson, D. B., Ko, J. S., Heidmann, T. & Medzhitov, R. Cell 134, 587–598 (2008).

    Article  CAS  Google Scholar 

  8. Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-Kirsch, M. A. & Lieberman, J. Nature Immunol. 11, 1005–1013 (2010).

    Article  CAS  Google Scholar 

  9. Kaushik, R., Zhu, X., Stranska, R., Wu, Y. & Stevenson, M. Cell Host Microbe 6, 68–80 (2009).

    Article  CAS  Google Scholar 

  10. Hirsch, V. M. et al. Nature Med. 4, 1401–1408 (1998).

    Article  CAS  Google Scholar 

  11. Manel, N. et al. Nature 467, 214–217 (2010).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Efrem S. Lim is in the Department of Microbiology, University of Washington, Seattle, Washington 98195-7242, USA.,

    Efrem S. Lim

  2. Michael Emerman is in the Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.,

    Michael Emerman

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  1. Efrem S. Lim
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  2. Michael Emerman
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Correspondence to Michael Emerman.

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Lim, E., Emerman, M. Going for the watchman. Nature 474, 587–588 (2011). https://doi.org/10.1038/474587a

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