Table of Contents

Japanese Table of Contents

Volume 474 Number 7349 pp5-120

2 June 2011

About the cover

Female blood-feeding mosquitoes in search of a meal are attracted by carbon dioxide exhaled in the breath of their vertebrate hosts. The CO2 detection machinery is a tempting target in the search for ways of disrupting disease transmission by insect vectors. Anandasankar Ray and colleagues have now identified volatile odorants that modify the CO2 detection pathway in the three deadliest mosquito species (Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus), and demonstrate the ability of odorants to disrupt CO2-mediated attraction behaviour. One compound has the novel property of causing ultra-prolonged activation of CO2-detecting nerve cells, with brief exposure resulting in prolonged disorientation. Others mimic or inhibit CO2 sensing. Compounds used in this proof-of-principle experiment, such as 2,3-butanedione, have properties that preclude use on humans, but this work could lead to the development of a new generation of insect repellents and lures that can work in small quantities. Cover background: A. Bradshaw/Getty.

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      • Vladimir Vacic
      • Shane McCarthy
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      • Fiona Murray
      • Hsun-Hua Chou
      • Aine Peoples
      • Vladimir Makarov
      • Seungtai Yoon
      • Abhishek Bhandari
      • Roser Corominas
      • Lilia M. Iakoucheva
      • Olga Krastoshevsky
      • Verena Krause
      • Verónica Larach-Walters
      • David K. Welsh
      • David Craig
      • John R. Kelsoe
      • Elliot S. Gershon
      • Suzanne M. Leal
      • Marie Dell Aquila
      • Derek W. Morris
      • Michael Gill
      • Aiden Corvin
      • Paul A. Insel
      • Jon McClellan
      • Mary-Claire King
      • Maria Karayiorgou
      • Deborah L. Levy
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