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Cancer

The flipside of Notch

Mutations that lead to increased activity of the Notch signalling pathway are well defined in human cancer. New work implicates decreased activity of this pathway in a type of blood cancer. See Letter p.230

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Figure 1: The Notch signalling pathway and blood disorders.

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Correspondence to Demetrios Kalaitzidis or Scott A. Armstrong.

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Kalaitzidis, D., Armstrong, S. The flipside of Notch. Nature 473, 159–160 (2011). https://doi.org/10.1038/473159a

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