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Translational medicine

To the rescue of the failing heart

Nature volume 473, pages 37–39 (2011)Cite this article

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Heart failure is characterized by weakened contractions of heart muscle. A drug that directly activates the key force-generating molecule in this muscle may be a valuable tool to strengthen the failing heart.

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Figure 1: How omecamtiv mecarbil functions.
Figure 2: Treating heart failure.

References

  1. Tang, W. H. & Francis, G. S. J. Am. Coll. Cardiol. 55, 688–696 (2010).

    Article  Google Scholar 

  2. Malik, F. I. et al. Science 331, 1439–1443 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Bers, D. M. Nature 415, 198–205 (2002).

    Article  ADS  CAS  Google Scholar 

  4. Kawase, Y., Ladage, D. & Hajjar, R. J. J. Am. Coll. Cardiol. 57, 1169–1180 (2011).

    Article  Google Scholar 

  5. Kushnir, A. & Marks, A. R. Adv. Pharmacol. 59, 1–30 (2010).

    Article  CAS  Google Scholar 

  6. Kass, D. A. & Solaro, R. J. Circulation 113, 305–315 (2006).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Donald M. Bers is in the Department of Pharmacology, University of California, Davis, Davis, California 95616, USA.,

    Donald M. Bers

  2. Samantha P. Harris is in the Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, California 95616, USA.,

    Samantha P. Harris

Authors
  1. Donald M. Bers
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  2. Samantha P. Harris
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Correspondence to Donald M. Bers.

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Bers, D., Harris, S. To the rescue of the failing heart. Nature 473, 37–39 (2011). https://doi.org/10.1038/473036a

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