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Developmental biology

A mouse is not a cow

Early cell-lineage decisions during embryonic development differ between mice and cows. This finding calls for a re-examination of developmental variations across mammals, but does not undermine use of the mouse as a model organism.

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Figure 1: Oct4 regulation in mouse and cow blastocysts.

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Correspondence to Janet Rossant.

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Rossant, J. A mouse is not a cow. Nature 471, 457–458 (2011). https://doi.org/10.1038/471457a

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