Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Reproductive biology

In vitro sperm maturation

Anticancer therapies can impair male fertility. Whereas men can opt to freeze their sperm before treatment, young boys don't produce mature sperm and so lack this choice. Work in mice offers hope for such patients. See Letter p.504

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Possible scenario for preserving fertility, based on the new work1.

References

  1. Sato, T. et al. Nature 471, 504–507 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Russell, L. D., Ettlin, R. A., Hikim, A. P. S. & Clegg, E. D. Histological and Histopathological Evaluation of the Testis (Cache River Press, 1990).

    Google Scholar 

  3. Staub, C. J. Androl. 22, 911–926 (2001).

    Article  CAS  Google Scholar 

  4. Gohbara, A. et al. Biol. Reprod. 83, 261–267 (2010).

    Article  CAS  Google Scholar 

  5. Price, P. J., Goldsborough, M. D. & Tilkins, M. L. International patent application: PCT/US98/00467 (1998).

  6. Brinster, R. L. & Zimmermann, J. W. Proc. Natl Acad. Sci. USA 91, 11298–11302 (1994).

    Article  ADS  CAS  Google Scholar 

  7. Kee, K., Angeles, V. T., Flores, M., Nguyen, H. N. & Reijo Pera, R. A. Nature 462, 222–225 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Nayernia, K. et al. Dev. Cell 11, 125–132 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Marco Seandel or Shahin Rafii.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seandel, M., Rafii, S. In vitro sperm maturation. Nature 471, 453–454 (2011). https://doi.org/10.1038/471453a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/471453a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing