Table of Contents

Japanese Table of Contents

Volume 471 Number 7338 pp265-402

17 March 2011

About the cover

The female steroid hormone progesterone is produced by the ovaries and the placenta, and supports gestation and embryogenesis through its actions on a well-characterized nuclear progesterone receptor. But progesterone released by cells surrounding the egg also stimulates sperm cells within the Fallopian tubes and increases their fertilizing ability, and the mechanism of this action of progesterone has remained elusive. Two independent research groups now report that progesterone potently activates CatSper, the principal Ca2+ channel of the sperm flagellum. Their data demonstrate that the CatSper channel or a directly associated membrane protein serves as a novel progesterone receptor that can mediate a fast, non-genomic effect of progesterone at the level of the sperm plasma membrane. These results should help to define the physiological role of progesterone and CatSper in sperm, and could lead to the development of new classes of non-hormonal contraceptives. Illustration by René Pascal/Center of Advanced European Study and Research, Bonn, Germany.

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  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

    • Hiroki Kaneko
    • Sami Dridi
    • Valeria Tarallo
    • Bradley D. Gelfand
    • Benjamin J. Fowler
    • Won Gil Cho
    • Mark E. Kleinman
    • Steven L. Ponicsan
    • William W. Hauswirth
    • Vince A. Chiodo
    • Katalin Karikó
    • Jae Wook Yoo
    • Dong-ki Lee
    • Majda Hadziahmetovic
    • Ying Song
    • Smita Misra
    • Gautam Chaudhuri
    • Frank W. Buaas
    • Robert E. Braun
    • David R. Hinton
    • Qing Zhang
    • Hans E. Grossniklaus
    • Jan M. Provis
    • Michele C. Madigan
    • Ann H. Milam
    • Nikki L. Justice
    • Romulo J. C. Albuquerque
    • Alexander D. Blandford
    • Sasha Bogdanovich
    • Yoshio Hirano
    • Jassir Witta
    • Elaine Fuchs
    • Dan R. Littman
    • Balamurali K. Ambati
    • Charles M. Rudin
    • Mark M. W. Chong
    • Patrick Provost
    • Jennifer F. Kugel
    • James A. Goodrich
    • Joshua L. Dunaief
    • Judit Z. Baffi
    • Jayakrishna Ambati
    See also
  • Crystal structure of a potassium ion transporter, TrkH

    • Yu Cao
    • Xiangshu Jin
    • Hua Huang
    • Mehabaw Getahun Derebe
    • Elena J. Levin
    • Venkataraman Kabaleeswaran
    • Yaping Pan
    • Marco Punta
    • James Love
    • Jun Weng
    • Matthias Quick
    • Sheng Ye
    • Brian Kloss
    • Renato Bruni
    • Erik Martinez-Hackert
    • Wayne A. Hendrickson
    • Burkhard Rost
    • Jonathan A. Javitch
    • Kanagalaghatta R. Rajashankar
    • Youxing Jiang
    • Ming Zhou