Induced pluripotent stem cells have great therapeutic potential. But genomic and epigenomic analyses of these cells generated using current technology reveal abnormalities that may affect their safe use. See Articles p.58, p.63 & p.68
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References
Hussein, S. M. et al. Nature 471, 58–62 (2011).
Gore, A. et al. Nature 471, 63–67 (2011).
Lister, R. et al. Nature 471, 68–73 (2011).
Mayshar, Y. et al. Cell Stem Cell 7, 521–531 (2010).
Laurent, L. C. et al. Cell Stem Cell 8, 106–118 (2011).
Baker, D. E. C. et al. Nature Biotechnol. 25, 207–215 (2007).
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Pera, M. The dark side of induced pluripotency. Nature 471, 46–47 (2011). https://doi.org/10.1038/471046a
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DOI: https://doi.org/10.1038/471046a
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