Fragile sites are genomic regions prone to deletions or other alterations during DNA replication. The reason for the susceptibility of these sites to damage may be simple: they contain few replication initiation sites. See Letter p.120
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Huebner, K. DNA fragility put into context. Nature 470, 46–47 (2011). https://doi.org/10.1038/470046a
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DOI: https://doi.org/10.1038/470046a
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