Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4–6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population ‘Denisovans’ and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.
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- Supplementary Information (4.5M)
This file contains 13 Supplementary Information sections (see Table of Contents), which include Supplementary Data, Supplementary Figures, Supplementary Tables and additional references. For Supplementary Data 1 Please go to the following link to access this file: http://bioinf.eva.mpg.de/download/DenisovaGenome/Denisova_Neandertal_catalog.tgz
- Supplementary Data 2 (60K)
This spreadsheet describes the 13 regions of potential admixture from Neandertals into modern humans as described in Green et al., Science 328:710 (2010).