Table of Contents

Japanese Table of Contents

Volume 468 Number 7325 pp731-862

9 December 2010

About the cover

The appearance of embryos in related species converges midway through development and diverges thereafter, a phenomenon known as the developmental hourglass. The hourglass model builds on classic observations by Karl Ernst von Baer, later popularized by Ernst Haeckel — Charles Darwin’s champion in Germany. But is this ‘phylotypic stage’ real? Two groups use contrasting methodology to test — and provide support for — the model. Genes expressed during the phylotypic stage are both evolutionarily older and more conserved across the genus than those expressed at other stages. On the cover, a version of Haeckel’s drawing of 1879 constructed from thousands of images of expression patterns during Drosophila embryogenesis. Picture credit: Pavel Tomancak

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