Enhancer sequences increase gene transcription with the help of a co-activator complex, the Mediator. Another protein complex — cohesin — seems to work with Mediator to bring together enhancers and promoters. See Article p. 430
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References
Taatjes, D. Trends Biochem. Sci. 35, 315–322 (2010).
Kagey, M. H. et al. Nature 467, 430–435 (2010).
Max, T., Sogaard, M. & Svejstrup, J. Q. J. Biol. Chem. 282, 14113–14120 (2009).
Wood, A. J., Severson, A. F. & Meyer, B. J. Nature Rev. Genet. 11, 391–404 (2010).
Carretero, M., Remeseiro, S. & Losada, A. Curr. Opin. Cell Biol. 22, 1–7 (2010).
Dorsett, D. Chromosome Res. 17, 185–200 (2009).
Schmidt, D. et al. Genome Res. 20, 578–588 (2010).
Philibert, R. A. & Madan, A. Pharmacogenomics 8, 909–916 (2007).
Liu, J. et al. PLoS Biol. 7, e1000119 (2009).
Schoenfelder, S., Clay, I. & Fraser, P. Curr. Opin. Genet. Dev. 20, 127–133 (2010).
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Ohlsson, R. The coherent Mediator. Nature 467, 406–407 (2010). https://doi.org/10.1038/467406a
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DOI: https://doi.org/10.1038/467406a
