Structural biology: Piston drives a proton pump

Journal name:
Nature
Volume:
465,
Pages:
428–429
Date published:
DOI:
doi:10.1038/465428a
Published online

The membrane-spanning enzyme known as complex I couples the movement of electrons to that of protons as a way of converting energy. Crystal structures suggest how electron transfer drives proton pumping from afar.

References

  1. Efremov, R. G., Baradaran, R. & Sazanov, L. A. Nature 465, 441445 (2010).
  2. Mitchell, P. Science 206, 11481159 (1979).
  3. Carroll, J., Fearnley, I. M., Shannon, R. J., Hirst, J. & Walker, J. E. Mol. Cell. Proteomics 2, 117126 (2003).
  4. Yagi, T., Yano, T., Di Bernardo, S. & Matsuno-Yagi, A. Biochim. Biophys. Acta 1364, 125133 (1998).
  5. Ohnishi, T. Biochim. Biophys. Acta 1364, 186206 (1998).
  6. Ohnishi, T. & Salerno, J. C. FEBS Lett. 579, 45554561 (2005).
  7. Hofhaus, G., Weiss, H. & Leonard, K. J. Mol. Biol. 221, 10271043 (1991).
  8. Sazanov, L. A. & Hinchliffe, P. Science 311, 14301436 (2006).
  9. Shinzawa-Itoh, K. et al. Biochemistry 49, 487492 (2010).
  10. Wikström, M. FEBS Lett. 169, 300304 (1984).
  11. Galkin, A. S., Grivennikova, V. G. & Vinogradov, A. D. FEBS Lett. 451, 157161 (1999).
  12. Friedrich, T. & Weiss H. J. Theor. Biol. 187, 529540 (1997).
  13. Hunte, C. et al. Nature 435, 11971202 (2005).
  14. Sazanov, L. A., Peak-Chew, S. Y., Fearnley, I. M. & Walker, J. E. Biochemistry 39, 72297235 (2000).
  15. Friedrich, T. J. Bioenerg. Biomembr. 33, 169177 (2001).
  16. Yagi, T. & Matsuno-Yagi, A. Biochemistry 42, 22662274 (2003).
  17. Brandt, U. Annu. Rev. Biochem. 75, 6992 (2006).
  18. Roth, R. & Hägerhäll, C. Biochim. Biophys. Acta 1504, 352362 (2001).
  19. Nakamaru-Ogiso, E. et al. FEBS Lett. 584, 883888 (2010).

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Affiliations

  1. Tomoko Ohnishi is in the Johnson Foundation, Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA.
    ohnishi@mail.med.upenn.edu

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