Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DNA repair

Decision at the break point

Many decisions affect the fate of damaged DNA — for example, how to repair the damage, or whether to repair it at all and instead let the damaged cell die. An intricate web of molecular interactions affects such decisions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Choosing the correct repair pathway for DNA double-strand breaks (DSBs).

References

  1. Bunting, S. F. et al. Cell 141, 243–254 (2010).

    Article  CAS  Google Scholar 

  2. Bouwman, P. et al. Nature Struct. Mol. Biol. doi:10.1038/nsmb.1831 (2010).

  3. Boulton, S. J. Biochem. Soc. Trans. 34, 633–645 (2006).

    Article  CAS  Google Scholar 

  4. Cao, L., Li, W., Kim, S., Brodie, S. G. & Deng, C.-X. Genes Dev. 17, 201–213 (2003).

    Article  CAS  Google Scholar 

  5. Xu, X. et al. Nature Genet. 28, 266–271 (2001).

    Article  CAS  Google Scholar 

  6. Cao, L. et al. Mol. Cell 35, 534–541 (2009).

    Article  CAS  Google Scholar 

  7. Yu, X., Fu, S., Lai, M., Baer, R. & Chen, J. Genes Dev. 20, 1721–1726 (2006).

    Article  CAS  Google Scholar 

  8. Morris, J. R. et al. Nature 462, 886–890 (2009).

    Article  ADS  CAS  Google Scholar 

  9. Galanty, Y. et al. Nature 462, 935–939 (2009).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boulton, S. Decision at the break point. Nature 465, 301–302 (2010). https://doi.org/10.1038/465301a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/465301a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing