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Editorials

Still prime time for primates p267

Rats turn out to be surprisingly useful for research on cognition. But if the goal is to understand the human brain and its many disorders, then primate studies remain essential.

doi:10.1038/465267a


Change of purpose p267

The United States should protect investments used to find new uses for old drugs.

doi:10.1038/465267b


Singular vision p268

Reforms that could harmonize and enhance European research deserve support.

doi:10.1038/465268a


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Research Highlights

Nanotechnology: Bacterial power p270

doi:10.1038/465270a


Neuroscience: Instant learning p270

doi:10.1038/465270b


Organic chemistry: Biofuel boost p270

doi:10.1038/465270c


Cancer: Melanoma's moving target p270

doi:10.1038/465270d


Ecology: No farm is an island p270

doi:10.1038/465270e


Cell biology: Viral vote p271

doi:10.1038/465271a


Neuroscience: Bright eyed p271

doi:10.1038/465271b


Physics: Not a WISP of evidence p271

doi:10.1038/465271c


Microbial genomics: A happy marriage p271

doi:10.1038/465271d


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Journal Club

Journal club p271

Marc Vrakking

doi:10.1038/465271e


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News

News briefing: 20 May 2010 p272

The week in science.

doi:10.1038/465272a


Oil cruise finds deep-sea plume p274

Nature reports from the research ship Pelican as scientists map the hidden extent of the Deepwater disaster.

Mark Schrope

doi:10.1038/465274a


Space-science hopes rest on rocket test p276

New launch vehicle could carry next generation of NASA's research probes.

Eric Hand

doi:10.1038/465276a


Neglected diseases fund touted p277

Initiative seeks billions of dollars to develop promising drugs and vaccines.

Declan Butler

doi:10.1038/465277a


Pact protects Canadian forests p279

Huge conservation deal will benefit caribou and maybe climate.

Christopher Pala

doi:10.1038/465279a


Malaria may not rise as world warms p280

Studies suggest that strategies to combat the disease are offsetting the impact of climate change.

Heidi Ledford

doi:10.1038/465280a


Pacific tuna population may crash at any time p280

Researchers warn that confidence in stock's health could be misplaced.

David Cyranoski

doi:10.1038/465280b


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Correction p281

doi:10.1038/465281a


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News Features

Neuroscience: The rat pack p282

Studying primates is the only way to understand human cognition — or so neuroscientists thought. But there may be much to learn from rats and mice, finds Alison Abbott.

doi:10.1038/465282a


Oceanography: Death and rebirth in the deep p284

When a submarine volcano erupts, the results can be devastating — and fascinating. Jane Qiu finds new drama in underwater biogeography.

doi:10.1038/465284a


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Column

World view: Disaster, unmitigated p287

An oil slick will not re-engage the public with environmental issues, warns Colin Macilwain, but it might lead to a saner US energy policy.

Colin Macilwain

doi:10.1038/465287a


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Correspondence

How government spending cuts put lives at risk p289

David Stuckler, Sanjay Basu & Martin McKee

doi:10.1038/465289a


Biodiversity: linking Singapore's fragmented habitats p289

Kwek Yan Chong, Alex Thiam Koon Yee & Chow Khoon Yeo

doi:10.1038/465289b


Biodiversity: need for balanced reports of solutions and failures p289

Tim Caro

doi:10.1038/465289c


Controls needed to reduce problem of plastic contamination p289

Andrei P. Sommer & Noah Lotan

doi:10.1038/465289d


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Opinions

Scientific steps to nuclear disarmament p290

An advisory group and a network of international labs is needed to lay the groundwork for multilateral disarmament and forge links between nations, say Martin Rees, Ben Koppelman and Neil Davison.

Martin Rees, Ben Koppelman & Neil Davison

doi:10.1038/465290a


Decentralize, adapt and cooperate p292

Two years ago Raphael D. Sagarin and colleagues proposed that security systems should learn from nature. Now they've worked with defence professionals on putting that call into practice.

Raphael D. Sagarin, Candace S. Alcorta, Scott Atran, Daniel T. Blumstein, Gregory P. Dietl, Michael E. Hochberg, Dominic D. P. Johnson, Simon Levin, Elizabeth M. P. Madin, Joshua S. Madin, Elizabeth M. Prescott, Richard Sosis, Terence Taylor, John Tooby & Geerat J. Vermeij

doi:10.1038/465292a


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Books and Arts

Science, freedom and trade p294

Michael Shermer enjoys two books that examine economics and politics from a scientific perspective — one explaining the experimental basis for democracy, another placing trade in an evolutionary context.

Michael Shermer reviews The Science of Liberty: Democracy, Reason, and the Laws of Nature by Timothy Ferris and The Rational Optimist: How Prosperity Evolves by Matt Ridley

doi:10.1038/465294a


A flowering of pleasure and pain p295

The latest collaborative artwork from neuroscientist Morten Kringelbach and artist Annie Cattrell reveals — and revels in — sensory dialogues in the brain, explains Martin Kemp.

Martin Kemp

doi:10.1038/465295a


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News and Views

Drug discovery: Priming the antimalarial pipeline p297

Emerging resistance to existing antimalarial drugs could nullify efforts to eliminate this deadly disease. The discovery of thousands of agents active against malaria parasites offers hope for developing new drugs.

David A. Fidock

doi:10.1038/465297a

See also: Editor's summary | Article by Gamo et al. | Article by Guiguemde et al.


Biomaterials: Intelligent glue p298

Spiders' webs are coated with microscopic droplets of glue, but the properties of this adhesive were unclear. It has now been found that the glue's stretchiness underpins its role in catching flies.

Haeshin Lee

doi:10.1038/465298a


Developmental biology: Roots respond to an inner calling p299

In plant roots, patterning of two types of water-conducting xylem tissue is determined by a signalling system that involves the reciprocal dance of a mobile transcription factor and mobile microRNAs.

Ben Scheres

doi:10.1038/465299a

See also: Editor's summary | Article by Carlsbecker et al.


Extrasolar planets: Larger than they ought to be p300

The finding that some gas-giant exoplanets are much larger than theory predicts has been boggling astronomers' minds. Planetary heating caused by gravitational tidal interactions might be a piece of the puzzle.

Pin-Gao Gu

doi:10.1038/465300a


DNA repair: Decision at the break point p301

Many decisions affect the fate of damaged DNA — for example, how to repair the damage, or whether to repair it at all and instead let the damaged cell die. An intricate web of molecular interactions affects such decisions.

Simon J. Boulton

doi:10.1038/465301a


Supernovae: New explosions of old stars? p303

Examples of stellar explosions have emerged that fall outside the traditional types of supernova. The nature of the stars that produce them and the mechanism by which they explode is far from clear.

David Branch

doi:10.1038/465303a

See also: Editor's summary | Letter by Perets et al. | Letter by Kawabata et al.


Global change: The ocean is warming, isn't it? p304

A reappraisal of the messy data on upper-ocean heat content for 1993–2008 provides clear evidence for warming. But differences among various analyses and inconsistencies with other indicators merit attention.

Kevin E. Trenberth

doi:10.1038/465304a

See also: Editor's summary | Letter by Lyman et al.


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Articles

Thousands of chemical starting points for antimalarial lead identification p305

Here, nearly 2 million compounds from GlaxoSmithKline's chemical library were screened for inhibitors of the malaria parasite Plasmodium falciparum, grown in red blood cells. Of these compounds, some 13,500 inhibited parasite growth, and more than 8,000 also showed potent activity against a multidrug resistant strain. The targets of these compounds were inferred through bioinformatic analysis, revealing several new mechanisms of antimalarial action.

Francisco-Javier Gamo, Laura M. Sanz, Jaume Vidal, Cristina de Cozar, Emilio Alvarez, Jose-Luis Lavandera, Dana E. Vanderwall, Darren V. S. Green, Vinod Kumar, Samiul Hasan, James R. Brown, Catherine E. Peishoff, Lon R. Cardon & Jose F. Garcia-Bustos

doi:10.1038/nature09107

See also: Editor's summary | News and Views by Fidock


Chemical genetics of Plasmodium falciparum p311

Here, a library of more than 300,000 chemicals was screened for activity against Plasmodium falciparum growing in red blood cells. Of these chemicals, 172 representative candidates were profiled in detail; one exemplar compound showed efficacy in a mouse model of malaria. The findings provide the scientific community with new starting points for drug discovery.

W. Armand Guiguemde, Anang A. Shelat, David Bouck, Sandra Duffy, Gregory J. Crowther, Paul H. Davis, David C. Smithson, Michele Connelly, Julie Clark, Fangyi Zhu, María B. Jiménez-Díaz, María S. Martinez, Emily B. Wilson, Abhai K. Tripathi, Jiri Gut, Elizabeth R. Sharlow, Ian Bathurst, Farah El Mazouni, Joseph W. Fowble, Isaac Forquer, Paula L. McGinley, Steve Castro, Iñigo Angulo-Barturen, Santiago Ferrer, Philip J. Rosenthal, Joseph L. DeRisi, David J. Sullivan, John S. Lazo, David S. Roos, Michael K. Riscoe, Margaret A. Phillips, Pradipsinh K. Rathod, Wesley C. Van Voorhis, Vicky M. Avery & R. Kiplin Guy

doi:10.1038/nature09099

See also: Editor's summary | News and Views by Fidock


Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate p316

A fundamental question in developmental biology is how cells communicate positional information to pattern the tissues of an organ. Here, the patterning of a plant's xylem tubes, which transport water and solutes from root to shoot, is studied. A new bidirectional signalling pathway is discovered, whereby a transcription factor moves from cell to cell in one direction, and microRNAs move in the other direction. The result is a differential distribution of target mRNA in the vascular cylinder, determining xylem cell types.

Annelie Carlsbecker, Ji-Young Lee, Christina J. Roberts, Jan Dettmer, Satu Lehesranta, Jing Zhou, Ove Lindgren, Miguel A. Moreno-Risueno, Anne Vatén, Siripong Thitamadee, Ana Campilho, Jose Sebastian, John L. Bowman, Ykä Helariutta & Philip N. Benfey

doi:10.1038/nature08977

See also: Editor's summary | News and Views by Scheres


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Letters

A faint type of supernova from a white dwarf with a helium-rich companion p322

Supernovae are thought to arise through one of two processes. Type Ib/c and type II supernovae are produced when the cores of massive, short-lived stars undergo gravitational core collapse and eject a few solar masses. Type Ia supernovae are thought to form by the thermonuclear detonation of a carbon-oxygen white dwarf. Here a faint type Ib supernova, SN 2005E, is reported that seems not to have had a core-collapse origin, but perhaps arose from a low-mass, old progenitor, probably a helium-accreting white dwarf in a binary.

H. B. Perets, A. Gal-Yam, P. A. Mazzali, D. Arnett, D. Kagan, A. V. Filippenko, W. Li, I. Arcavi, S. B. Cenko, D. B. Fox, D. C. Leonard, D.-S. Moon, D. J. Sand, A. M. Soderberg, J. P. Anderson, P. A. James, R. J. Foley, M. Ganeshalingam, E. O. Ofek, L. Bildsten, G. Nelemans, K. J. Shen, N. N. Weinberg, B. D. Metzger, A. L. Piro, E. Quataert, M. Kiewe & D. Poznanski

doi:10.1038/nature09056

See also: Editor's summary | News and Views by Branch


A massive star origin for an unusual helium-rich supernova in an elliptical galaxy p326

The unusual supernova SN 2005E is distinguished from any supernovae hitherto observed by several features, which are claimed to be explained by a helium detonation in a thin surface layer of an accreting white dwarf. The observed properties of SN 2005cz are now shown to resemble those of SN 2005E. It is argued that these properties are best explained by a core-collapse supernova at the low-mass end of the range of massive stars that explode.

K. S. Kawabata, K. Maeda, K. Nomoto, S. Taubenberger, M. Tanaka, J. Deng, E. Pian, T. Hattori & K. Itagaki

doi:10.1038/nature09055

See also: Editor's summary | News and Views by Branch


GaAs photovoltaics and optoelectronics using releasable multilayer epitaxial assemblies p329

Although compound semiconductors like gallium arsenide (GaAs) offer advantages over silicon for photovoltaic and optoelectronic applications, these do not outweigh the costly process of growing large layers of these materials and transferring them to appropriate substrates. However, a new fabrication approach is now demonstrated: films of GaAs and AlGaAs are grown in thick, multilayered assemblies in a single sequence; the individual layers are then released and distributed over foreign substrates by printing.

Jongseung Yoon, Sungjin Jo, Ik Su Chun, Inhwa Jung, Hoon-Sik Kim, Matthew Meitl, Etienne Menard, Xiuling Li, James J. Coleman, Ungyu Paik & John A. Rogers

doi:10.1038/nature09054

See also: Editor's summary


Robust warming of the global upper ocean p334

The upper 300 m of the world's oceans act as a giant heat sink and have absorbed the majority of the excess energy generated by anthropogenic greenhouse gases. But the magnitude of the oceanic heat uptake is uncertain, and differing estimates have led to questions regarding the closure of the global energy budget. Here, a comparison of ocean heat content estimates is presented; the conclusion is that a robust warming of 0.64 W m−2 occurred from 1993 to 2008.

John M. Lyman, Simon A. Good, Viktor V. Gouretski, Masayoshi Ishii, Gregory C. Johnson, Matthew D. Palmer, Doug M. Smith & Josh K. Willis

doi:10.1038/nature09043

See also: Editor's summary | News and Views by Trenberth


Reconciling surface plate motions with rapid three-dimensional mantle flow around a slab edge p338

The direction of tectonic plate motion at the Earth's surface and the flow field of the mantle inferred from seismic anisotropy are well correlated globally, implying large-scale coupling between the mantle and surface plates. But the fit is poor at subduction zones. Here, three-dimensional numerical models of buoyancy-driven deformation for the Alaska subduction–transform system are used to find the origin of the regional decoupling of flow. The results imply local rapid transport of geochemical signatures through subduction zones.

Margarete A. Jadamec & Magali I. Billen

doi:10.1038/nature09053

See also: Editor's summary


Climate change and the global malaria recession p342

Rising global temperatures resulting from climate change have been predicted to increase the future incidence of infectious diseases, including malaria. However, it is known that the range of malaria has contracted through a century of economic development and disease control. This contraction has now been quantified, and compared with the predicted effects of climate on malaria incidence. It is suggested that the impact of rising temperature is likely to be minor.

Peter W. Gething, David L. Smith, Anand P. Patil, Andrew J. Tatem, Robert W. Snow & Simon I. Hay

doi:10.1038/nature09098

See also: Editor's summary


Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization p346

Staphylococcus epidermis is a commensal bacterium found in the human nasal cavity. It is now shown that a subset of S. epidermis secretes the serine protease Esp, and that this directly reduces the colonization of the nasal cavity by the pathogen S. aureus. The findings reveal a new mechanism of bacterial interference, which could lead to the development of new drugs to prevent S. aureus colonization and infection.

Tadayuki Iwase, Yoshio Uehara, Hitomi Shinji, Akiko Tajima, Hiromi Seo, Koji Takada, Toshihiko Agata & Yoshimitsu Mizunoe

doi:10.1038/nature09074

See also: Editor's summary


Effects of thymic selection of the T-cell repertoire on HLA classI-associated control of HIV infection p350

'Elite controllers' are rare people who are infected with HIV but maintain low levels of HIV RNA without being treated, making it unlikely that they will develop AIDS. Certain HLA class I alleles, notably HLA-B57, are enriched in elite controllers. Here a model is proposed to explain how such elite controllers generate an effective immune response against HIV. In this model, HLA-B57 binds to fewer self-peptides, resulting in a T-cell repertoire with enhanced cross-reactivity and leading to a more effective T-cell response to the virus.

Andrej Košmrlj, Elizabeth L. Read, Ying Qi, Todd M. Allen, Marcus Altfeld, Steven G. Deeks, Florencia Pereyra, Mary Carrington, Bruce D. Walker & Arup K. Chakraborty

doi:10.1038/nature08997

See also: Editor's summary


Modulation of Shigella virulence in response to available oxygen in vivo p355

The bacterium Shigella flexneri, which causes dysentery, infects the gastrointestinal tract. It uses a type III secretion system as a molecular syringe to inject virulence factors into host cells during infection. It is now suggested that varying oxygen availability during different phases of infection tightly regulates expression of the secretion system, as well as the secretion of virulence factors.

Benoit Marteyn, Nicholas P. West, Douglas F. Browning, Jeffery A. Cole, Jonathan G. Shaw, Fredrik Palm, Joelle Mounier, Marie-Christine Prévost, Philippe Sansonetti & Christoph M. Tang

doi:10.1038/nature08970

See also: Editor's summary


Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma p359

Toxoplasma gondii is an opportunistic human pathogen that secretes organelles called micronemes during infection. This is important for parasite motility, host-cell invasion and egress. It is now shown that the secretion of micronemes is dependent on the T. gondii calcium-dependent protein kinase 1. This kinase is not found in the parasite's mammalian hosts, and might represent a valid drug target.

Sebastian Lourido, Joel Shuman, Chao Zhang, Kevan M. Shokat, Raymond Hui & L. David Sibley

doi:10.1038/nature09022

See also: Editor's summary


A three-dimensional model of the yeast genome p363

The topologies of, and spatial relationships between, chromosomes are important but poorly understood. Here, a high-throughput method is used to study intra- and inter-chromosomal interactions in Saccharomyces cerevisiae. A map of the haploid genome is generated at kilobase resolution, and is used to construct a three-dimensional model of the yeast genome. The findings provide a glimpse of the interface between the form and function of a eukaryotic genome.

Zhijun Duan, Mirela Andronescu, Kevin Schutz, Sean McIlwain, Yoo Jung Kim, Choli Lee, Jay Shendure, Stanley Fields, C. Anthony Blau & William S. Noble

doi:10.1038/nature08973

See also: Editor's summary


Opposing roles for calcineurin and ATF3 in squamous skin cancer p368

Calcineurin inhibitors are the mainstay of immunosuppressive treatment for organ transplant recipients. However, treatment with these drugs commonly leads to squamous cell carcinoma (SCC) of the skin. It is shown here that an intact calcineurin/NFAT signalling pathway is important for suppressing SCC development. Inhibition of this pathway leads to increased expression of the ATF3 protein, which has a key role in tumorigenesis.

Xunwei Wu, Bach-Cuc Nguyen, Piotr Dziunycz, Sungeun Chang, Yang Brooks, Karine Lefort, Günther F. L. Hofbauer & G. Paolo Dotto

doi:10.1038/nature08996

See also: Editor's summary


Myosin II contributes to cell-scale actin network treadmilling through network disassembly p373

Eukaryotic cells crawl through a process in which the front of the cell is propelled forwards by the force provided by polymerization of actin filaments. These must be disassembled at the rear of the cell to allow sustained motility. It is now shown that non-muscle myosin II protein is needed for the disassembly of actin networks at the rear of crawling cells.

Cyrus A. Wilson, Mark A. Tsuchida, Greg M. Allen, Erin L. Barnhart, Kathryn T. Applegate, Patricia T. Yam, Lin Ji, Kinneret Keren, Gaudenz Danuser & Julie A. Theriot

doi:10.1038/nature08994

See also: Editor's summary


eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation p378

The initiation of protein synthesis requires the eukaryotic translation initiation factor (eIF) 2, which uses energy from the hydrolysis of GTP. Another factor, eIF5, accelerates the GTP-hydrolysing activity of eIF2. Here, two other roles for eIF5 have been defined. One involves stabilizing GDP, the product of GTP hydrolysis, on eIF2. In its other role, eIF5 works with phosphorylated eIF2 to inhibit the guanine-nucleotide exchange factor eIF2B. These results clarify our understanding of how the initiation of translation is regulated.

Martin D. Jennings & Graham D. Pavitt

doi:10.1038/nature09003

See also: Editor's summary


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Naturejobs

Careers Q&A

Chang-Hwan Choi p385

Chang-Hwan Choi, a nanoengineer at the Stevens Institute of Technology in Hoboken, New Jersey, received a 2010 Young Investigator Program award from the US Office of Naval Research (ONR) for his design of anti-corrosion surfaces that will make Navy vessels more durable.

Virginia Gewin

doi:10.1038/nj7296-385a


In Brief

Wellcome funding change p385

Streamlined grants get rolled out.

doi:10.1038/nj7296-385b


Arizona boycotted p385

Hispanic and Native American scientists take action over immigration law.

doi:10.1038/nj7296-385c


Non-tenure survey mixed p385

Job security proves a worry, although flexibility is welcome.

doi:10.1038/nj7296-385d


Careers and Recruitment

Burdens of biodefence p386

Working with nature's nastiest microbes offers a chance to help ensure public safety. Karen Kaplan details the profession's risks and rewards.

Karen Kaplan

doi:10.1038/nj7296-386a


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Futures

Mind expeditions p390

Fighting the good fight.

Brenda Cooper

doi:10.1038/465390a


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