Resistance of tumours to a common chemotherapy drug called cisplatin is linked to improved DNA repair in mouse models of lung cancer, researchers have found.
Cisplatin damages DNA and is used to treat various cancers. However, most tumours that respond to the drug eventually become resistant. Tyler Jacks at the Massachusetts Institute of Technology in Cambridge and his colleagues found that tumours that had been treated with cisplatin over 12 weeks cleared damaged DNA more quickly than previously untreated cancers. Long-term cisplatin use was also associated with higher expression of genes involved in DNA repair.
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Cancer biology: Cells combat chemo. Nature 464, 1107 (2010). https://doi.org/10.1038/4641107a
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DOI: https://doi.org/10.1038/4641107a
