Nature 464, 392-395 (18 March 2010) | doi:10.1038/nature08907; Received 13 November 2009; Accepted 8 February 2010

Shell-isolated nanoparticle-enhanced Raman spectroscopy

Jian Feng Li1, Yi Fan Huang1, Yong Ding2, Zhi Lin Yang1, Song Bo Li1, Xiao Shun Zhou1, Feng Ru Fan1,2, Wei Zhang1, Zhi You Zhou1, De Yin Wu1, Bin Ren1, Zhong Lin Wang2 & Zhong Qun Tian1

  1. State Key Laboratory of Physical Chemistry of Solid Surfaces and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
  2. School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332–0245, USA

Correspondence to: Zhong Lin Wang2Zhong Qun Tian1 Correspondence and requests for materials should be addressed to Z.Q.T. (Email: zqtian@xmu.edu.cn) and Z.L.W. (Email: zhong.wang@mse.gatech.edu).

Surface-enhanced Raman scattering (SERS) is a powerful spectroscopy technique that can provide non-destructive and ultra-sensitive characterization down to single molecular level, comparable to single-molecule fluorescence spectroscopy1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15. However, generally substrates based on metals such as Ag, Au and Cu, either with roughened surfaces or in the form of nanoparticles, are required to realise a substantial SERS effect, and this has severely limited the breadth of practical applications of SERS. A number of approaches have extended the technique to non-traditional substrates14, 16, 17, most notably tip-enhanced Raman spectroscopy (TERS)18, 19, 20 where the probed substance (molecule or material surface) can be on a generic substrate and where a nanoscale gold tip above the substrate acts as the Raman signal amplifier. The drawback is that the total Raman scattering signal from the tip area is rather weak, thus limiting TERS studies to molecules with large Raman cross-sections. Here, we report an approach, which we name shell-isolated nanoparticle-enhanced Raman spectroscopy, in which the Raman signal amplification is provided by gold nanoparticles with an ultrathin silica or alumina shell. A monolayer of such nanoparticles is spread as ‘smart dust’ over the surface that is to be probed. The ultrathin coating keeps the nanoparticles from agglomerating, separates them from direct contact with the probed material and allows the nanoparticles to conform to different contours of substrates. High-quality Raman spectra were obtained on various molecules adsorbed at Pt and Au single-crystal surfaces and from Si surfaces with hydrogen monolayers. These measurements and our studies on yeast cells and citrus fruits with pesticide residues illustrate that our method significantly expands the flexibility of SERS for useful applications in the materials and life sciences, as well as for the inspection of food safety, drugs, explosives and environment pollutants.


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