Nature 464, 217-223 (11 March 2010) | doi:10.1038/nature08757

Targeting early infection to prevent HIV-1 mucosal transmission

Ashley T. Haase1

Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.

  1. Department of Microbiology, University of Minnesota, Minnesota 55455, USA

Correspondence to: Ashley T. Haase1 Correspondence should be addressed to the author (Email:


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