Researchers have met the challenge of capturing transient states of the SUMO E1 activating enzyme. Their pictures show radically different crystal structures for two of the steps in this enzyme's activity.
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Schulman, B., Haas, A. Transformative encounters. Nature 463, 889–890 (2010). https://doi.org/10.1038/463889a
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DOI: https://doi.org/10.1038/463889a
