Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.
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ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity
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References
Kirkwood, T. B. L. Nature 270, 301–304 (1977).
Flatt, T. & Schmidt, P. Biochim. Biophys. Acta 1790, 951–962 (2009).
Grandison, R. C., Piper, M. D. W. & Partridge, L. Nature 462, 1061–1064 (2009).
Mair, W. & Dillin, A. Annu. Rev. Biochem. 77, 727–754 (2008).
Skorupa, D. A., Dervisefendic, A., Zwiener, J. & Pletcher, S. D. Aging Cell 7, 478–490 (2008).
Min, K.-J. & Tatar, M. Mech. Ageing Dev. 127, 643–646 (2006).
Troen, A. M. et al. Age 29, 29–39 (2007).
Miller, R. A. et al. Aging Cell 4, 119–125 (2005).
Zid, B. M. et al. Cell 139, 149–160 (2009).
Géminard, C., Rulifson, E. J. & Léopold, P. Cell Metab. 10, 199–207 (2009).
Tatar, M. & Carey, J. R. Ecology 76, 2066–2073 (1995).
Crawford, D., Libina, N. & Kenyon, C. Aging Cell 6, 715–721 (2007).
Wang, M. C., O'Rourke, E. J. & Ruvkun, G. Science 322, 957–960 (2008).
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Flatt, T. Diet and longevity in the balance. Nature 462, 989–990 (2009). https://doi.org/10.1038/462989a
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DOI: https://doi.org/10.1038/462989a
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