FIGURE 2. Rate of discovery of protein families as a function of phylogenetic breadth of genomes.

From the following article:

A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea

Dongying Wu, Philip Hugenholtz, Konstantinos Mavromatis, Rüdiger Pukall, Eileen Dalin, Natalia N. Ivanova, Victor Kunin, Lynne Goodwin, Martin Wu, Brian J. Tindall, Sean D. Hooper, Amrita Pati, Athanasios Lykidis, Stefan Spring, Iain J. Anderson, Patrik D’haeseleer, Adam Zemla, Mitchell Singer, Alla Lapidus, Matt Nolan, Alex Copeland, Cliff Han, Feng Chen, Jan-Fang Cheng, Susan Lucas, Cheryl Kerfeld, Elke Lang, Sabine Gronow, Patrick Chain, David Bruce, Edward M. Rubin, Nikos C. Kyrpides, Hans-Peter Klenk & Jonathan A. Eisen

Nature 462, 1056-1060(24 December 2009)

doi:10.1038/nature08656

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For each of four groupings (species, different strains of Streptococcus agalactiae; family, Enterobacteriaceae; phylum, Actinobacteria; domain, GEBA bacteria), all proteins from that group were compared to each other to identify protein families. Then the total number of protein families was calculated as genomes were progressively sampled from the group (starting with one genome until all were sampled). This was done multiple times for each of the four groups using random starting seeds; the average and standard deviation were then plotted.

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