Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunology

In the beginning

Nature volume 462, pages 41–42 (2009)Cite this article

Immune cells cross the inflamed blood–brain barrier. But it's unclear how brain inflammation begins before immune-cell entry. Studies of a model of multiple sclerosis start to solve this 'chicken and egg' conundrum.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The first wave of immune-cell entry.
Figure 2: The second wave.

References

  1. Glabinski, A. R., Tani, M., Tuohy, V. K., Tuthill, R. J. & Ransohoff, R. M. Brain Behav. Immun. 9, 315–330 (1995).

    Article  CAS  Google Scholar 

  2. Gerard, C. & Rollins, B. J. Nature Immunol. 2, 108–115 (2001). | Article

    Article  CAS  Google Scholar 

  3. Piccio, L. et al. J. Immunol. 168, 1940–1949 (2002).

    Article  CAS  Google Scholar 

  4. Reboldi, A. et al. Nature Immunol. 10, 514–523 (2009).

    Article  CAS  Google Scholar 

  5. Bartholomäus, I. et al. Nature 462, 94–98 (2009).

    Article  ADS  Google Scholar 

  6. Galea, I., Bechmann, I. & Perry, V. H. Trends Immunol. 28, 12–18 (2007).

    Article  CAS  Google Scholar 

  7. Ransohoff, R. M. Nature 457, 155–156 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Kivisakk, P. et al. Ann. Neurol. 65, 457–469 (2009).

    Article  CAS  Google Scholar 

  9. Kivisakk, P. et al. Proc. Natl Acad. Sci. USA 100, 8389–8394 (2003).

    Article  ADS  Google Scholar 

  10. Ransohoff, R. M., Kivisakk, P. & Kidd, G. Nature Rev. Immunol. 3, 569–581 (2003).

    Article  CAS  Google Scholar 

  11. Kawakami, N. et al. J. Exp. Med. 199, 185–197 (2004).

    Article  CAS  Google Scholar 

  12. Brown, D. A. & Sawchenko, P. E. J. Comp. Neurol. 502, 236–260 (2007).

    Article  Google Scholar 

  13. Axtell, R. C. & Steinman, L. Nature Immunol. 10, 453–455 (2009).

    Article  CAS  Google Scholar 

  14. Xu, H. et al. J. Neuroimmunol. 142, 47–57 (2003).

    Article  CAS  Google Scholar 

  15. Schenkel, A. R., Mamdouh, Z. & Muller, W. A. Nature Immunol. 5, 393–400 (2004). | Article

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Richard M. Ransohoff is in the Neuroinflammation Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. ransohr@ccf.org ,

    Richard M. Ransohoff

Authors
  1. Richard M. Ransohoff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ransohoff, R. In the beginning. Nature 462, 41–42 (2009). https://doi.org/10.1038/462041a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/462041a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing