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Nature 460, 753-757 (1 July 2009) | doi:10.1038/nature08192;
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Common variants on chromosome 6p22.1 are associated with schizophrenia
Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5–1%, with high heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high-penetrance copy number variants in some cases, but the genes or biological mechanisms that underlie susceptibility are not known.
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