Editor's Summary

6 August 2009

Schizophrenia risk: link to chromosome 6p22.1

A genome-wide association study using the Molecular Genetics of Schizophrenia case-control data set, followed by a meta-analysis that included over 8,000 cases and 19,000 controls, revealed that while common genetic variation that underlies risk to schizophrenia can be identified, there probably are few or no single common loci with large effects. The common variants identified here lie on chromosome 6p22.1 in a region that includes a histone gene cluster and several genes implicated in immunity.

Letter: Common variants on chromosome 6p22.1 are associated with schizophrenia

Jianxin Shi, Douglas F. Levinson, Jubao Duan, Alan R. Sanders, Yonglan Zheng, Itsik Pe'er, Frank Dudbridge, Peter A. Holmans, Alice S. Whittemore, Bryan J. Mowry, Ann Olincy, Farooq Amin, C. Robert Cloninger, Jeremy M. Silverman, Nancy G. Buccola, William F. Byerley, Donald W. Black, Raymond R. Crowe, Jorge R. Oksenberg, Daniel B. Mirel, Kenneth S. Kendler, Robert Freedman & Pablo V. Gejman

doi:10.1038/nature08192

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