Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 460, 466-467 (23 July 2009) | doi:10.1038/460466a; Published online 22 July 2009
Open Innovation Challenges
-
Methods to Analyze Consumer Emotions
The Seeker is looking for methods to analyze consumer emotions. This Challenge requires only a writ...
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
- More Challenges
- Powered by:
nature jobs
Associate Scientific Manager / Scientific Manager-Organic / Medicinal Chemistry
- Syngene International
- Bangalore, Karnataka 560099 India
Manager Client Services
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
Cancer: Three birds with one stone
Franck Toledo1 & Boris Bardot1
Abstract
The core domain of the p53 protein has been found to affect microRNA processing — its third known antitumour activity. Most cancerous p53 mutations affect this domain and may abolish all tumour-suppressor functions.
The p53 protein is a major tumour suppressor. The gene that encodes it (TP53) is mutated in about half of human cancers, and most remaining tumours find other ways to inactivate the p53 pathway1.
- Franck Toledo and Boris Bardot are in the Genetics of Tumor Suppression Group, Institut Curie, 75248 Paris Cedex 05, France, and at the Université Pierre et Marie Curie Paris 06, Paris, France.
Email: franck.toledo@curie.fr
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Research highlightsNature Structural & Molecular Biology News and Views (01 May 2007)
MicroRNAs as tumor suppressorsNature Genetics News and Views (01 May 2007)
See all 7 matches for News And ViewsRESEARCH
Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3BOncogene Original Article
Colorectal cancer cells with the BRAF V600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIMOncogene Original Article
See all 23 matches for Research