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Cancer

Three birds with one stone

Nature volume 460, pages 466–467 (2009)Cite this article

The core domain of the p53 protein has been found to affect microRNA processing — its third known antitumour activity. Most cancerous p53 mutations affect this domain and may abolish all tumour-suppressor functions.

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Figure 1: Three antitumour functions.

References

  1. Toledo, F. & Wahl, G. M. Nature Rev. Cancer 6, 909–923 (2006).

    Article  CAS  Google Scholar 

  2. Green, D. R. & Kroemer, G. Nature 458, 1127–1130 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Suzuki, H. I. et al. Nature 460, 529–533 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Ventura, A. & Jacks, T. Cell 136, 586–591 (2009).

    Article  CAS  Google Scholar 

  5. He, L., He, X., Lowe, S. W. & Hannon, G. J. Nature Rev. Cancer 7, 819–822 (2007).

    Article  CAS  Google Scholar 

  6. Lozano, G. Curr. Opin. Genet. Dev. 17, 66–70 (2007).

    Article  CAS  Google Scholar 

  7. Suh, E.-K. et al. Nature 444, 624–628 (2006).

    Article  ADS  CAS  Google Scholar 

  8. Bourdon, J.-C. et al. Genes Dev. 19, 2122–2137 (2005).

    Article  CAS  Google Scholar 

  9. Whibley, C., Pharoah, P. D. P. & Hollstein, M. Nature Rev. Cancer 9, 95–107 (2009).

    Article  CAS  Google Scholar 

  10. Vazquez, A., Bond, E. E., Levine, A. J. & Bond, G. L. Nature Rev. Drug Discov. 7, 979–987 (2008).

    Article  CAS  Google Scholar 

  11. Vousden, K. H. & Lane, D. P. Nature Rev. Mol. Cell Biol. 8, 275–283 (2007).

    Article  CAS  Google Scholar 

  12. Fuller-Pace, F. V. Nucleic Acids Res. 34, 4206–4215 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Franck Toledo and Boris Bardot are in the Genetics of Tumor Suppression Group, Institut Curie, 75248 Paris Cedex 05, France, and at the Université Pierre et Marie Curie Paris 06, Paris, France. franck.toledo@curie.fr ,

    Franck Toledo & Boris Bardot

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  1. Franck Toledo
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  2. Boris Bardot
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Toledo, F., Bardot, B. Three birds with one stone. Nature 460, 466–467 (2009). https://doi.org/10.1038/460466a

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