Editor's Summary
23 July 2009
Fast reaction of a CREB coactivator
In fasted mammals, circulating pancreatic glucagon stimulates gluconeogenesis in the liver in part through the CREB coactivator CRTC2/TORC2. CRTC2 is now shown to function as a dual sensor for fasting signals and endoplasmic reticulum (ER) stress in the liver. Crosstalk between fasting and ER stress pathways at the level of this transcriptional coactivator contributes to glucose homeostasis under lean conditions and to the development of hyperglycaemia in obesity.
Authors: Abstractions
doi:10.1038/7254434b
Letter: The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
Yiguo Wang, Liliana Vera, Wolfgang H. Fischer & Marc Montminy
doi:10.1038/nature08111
First paragraph | Full Text | PDF (614K) | Supplementary information
