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Nature 460, 392-395 (8 July 2009) | doi:10.1038/nature08221;
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.
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