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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

David E. Harrison, Randy Strong, Zelton Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, J. Erby Wilkinson, Krystyna Frenkel, Christy S. Carter, Marco Pahor, Martin A. Javors, Elizabeth Fernandez & Richard A. Miller

Nature 460, 392-395(16 July 2009)

doi:10.1038/nature08221

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Survival plots for male and female mice, comparing control mice to those fed rapamycin in the diet starting at 600 days of age, pooling across the three test sites.

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Figure 2

Survival of control and rapamycin-treated mice for males and females for each of the three test sites separately.

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Figure 3

Characterization of mice receiving rapamycin from 270 days of age.

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Table 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Table 1

The effect of rapamycin on maximum lifespan

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