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From the following article:

A conserved ubiquitination pathway determines longevity in response to diet restriction

Andrea C. Carrano, Zheng Liu, Andrew Dillin & Tony Hunter

Nature 460, 396-399(16 July 2009)

doi:10.1038/nature08130

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Figure 1

wwp-1 is required and specific for the extension of lifespan by dietary restriction.

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Figure 2

WWP-1 ubiquitin ligase activity is essential for diet-restriction-induced longevity.

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Figure 3

WWP-1 exhibits ubiquitin ligase activity in a UBC-18 dependent manner in vitro.

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Figure 4

WWP-1 and UBC-18 function together to regulate diet-restriction-induced longevity.

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