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Nature 460, 113-117 (2 July 2009) | doi:10.1038/nature08191;
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Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages
The generation and expansion of diverse cardiovascular cell lineages is a critical step during human cardiogenesis, with major implications for congenital heart disease. Unravelling the mechanisms for the diversification of human heart cell lineages has been hampered by the lack of genetic tools to purify early cardiac progenitors and define their developmental potential.
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