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Nature 460, 39-40 (2 July 2009) | doi:10.1038/460039a; Published online 1 July 2009

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Developmental biology: A cellular view of regeneration

Alejandro Sánchez Alvarado1

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How the salamander regrows an entire limb after injury has flummoxed the wisest of scientists. A closer look at the cells involved in limb regeneration shows that remembering past origins may be crucial for this feat.

When a salamander loses an appendage, such as a limb, a remarkable series of events unfolds: a clump of cells forms at the site of the injury, and this deceptively simple structure, known as a blastema, regenerates the missing body parts. Skin, muscle, bone, blood vessels and neurons all arise from this collection of nondescript cells through patterning and self-assembly.

  1. Alejandro Sánchez Alvarado is in the Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
    Email: sanchez@neuro.utah.edu

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RESEARCH

Cells keep a memory of their tissue origin during axolotl limb regeneration

Nature Article (02 Jul 2009)