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Telomerase modulates Wnt signalling by association with target gene chromatin

Jae-Il Park, Andrew S. Venteicher, Ji Yeon Hong, Jinkuk Choi, Sohee Jun, Marina Shkreli, Woody Chang, Zhaojing Meng, Peggie Cheung, Hong Ji, Margaret McLaughlin, Timothy D. Veenstra, Roel Nusse, Pierre D. McCrea & Steven E. Artandi

Nature 460, 66-72(2 July 2009)

doi:10.1038/nature08137

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

TERT activates Wnt reporter plasmids in a BRG1-dependent manner.

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Figure 2

TERT activates the Wnt pathway in vivo and is required for efficient target gene activation by WNT3A ligand in mouse ES cells.

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Figure 3

TERT promotes anterior–posterior axis duplication and is required for efficient anterior–posterior axis in Xenopus.

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Figure 4

Somite defects in Xenopus embryos treated with TERT morpholino and homeotic transformations in Tert-/- mice.

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Figure 5

TERT occupies Wnt target gene promoters in HeLa cells and in mouse small intestine.

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