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From the following article:
Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase
Nisheeth Agarwal, Gyanu Lamichhane, Radhika Gupta, Scott Nolan & William R. Bishai
Nature 460, 98-102(2 July 2009)
doi:10.1038/nature08123
Figure 1
The M. tuberculosis-induced macrophage cAMP burst and CREB phosphorylation pathway require live bacilli but not host GPCR-AC.
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Figure 2
Overexpression of phosphodiesterase Rv0805 in M. tuberculosis reduces intramacrophage cAMP levels, CREB phosphorylation, and TNF-
secretion in infected J774 cells.
Figure 3
The M. tuberculosis Rv0386 mutant shows reduced mouse virulence, and lower levels of intramacrophage cAMP, CREB phosphorylation, and TNF- secretion.
Figure 4
Bacterial-derived cAMP enters the macrophage cytosol after infection.
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