Progress
Nature 460, 49-52 (2 July 2009) | doi:10.1038/nature08180; Received 20 February 2009; Accepted 29 May 2009
Elite and stochastic models for induced pluripotent stem cell generation
Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.
- Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
- Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Correspondence to: Shinya Yamanaka1,2 Correspondence should be addressed to S.Y. (Email: yamanaka@cira.kyoto-u.ac.jp).
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