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News and Views
Nature 459, 1068-1069 (25 June 2009) | doi:10.1038/4591068a; Published online 24 June 2009
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Stem cells: The stress of forming blood cells
Luc Pardanaud1 & Anne Eichmann1
Abstract
The first heartbeat is an important moment in an embryo's life. The biomechanical forces created by pulsatile flow promote the formation of haematopoietic stem cells that equip the body with its mature blood cells.
Haematopoietic stem cells (HSCs) are rare cells that can self-renew and generate all types of mature blood cell. Adult HSCs reside in the bone marrow and function throughout life, but during embryonic development they are first formed in close association with the endothelial lining of embryonic blood vessels, before the marrow appears.
- Luc Pardanaud and Anne Eichmann are at Inserm U833, Collège de France, 75005 Paris, France.
Email: anne.eichmann@college-de-france.fr
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