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Nature 459, 787-788 (11 June 2009) | doi:10.1038/459787a; Published online 10 June 2009
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Cell biology: The proteasome assembly line
Kiran Madura1
Abstract
The assembly of the proteasome — the cellular machine that eliminates unwanted proteins — is a carefully choreographed affair, involving a complex sequence of steps overseen by dedicated protein chaperones.
The proteasome degrades faulty or superfluous intracellular proteins, which are targeted to it for destruction by the attachment of the small ubiquitin protein. This multi-protein complex consists of a barrel-shaped core particle, which enzymatically degrades proteins, bound to one or two outer regulatory particles.
- Kiran Madura is in the Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
Email: maduraki@umdnj.edu
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