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News and Views
Nature 459, 784-786 (11 June 2009) | doi:10.1038/459784a; Published online 10 June 2009; Corrected 11 June 2009
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Immunology: Immunity's ancient arms
Gary W. Litman1 & John P. Cannon1
Abstract
Diverse receptors on two types of cell mediate adaptive immunity in jawed vertebrates. In the lamprey, a jawless vertebrate, immunity is likewise compartmentalized but the molecular mechanics are very different.
About 500 million years ago, vertebrates divided into two forms marked by the possession or lack of jaws. Today, the jawed forms are by far the more common and include organisms as diverse as humans and sharks.
- Gary W. Litman and John P. Cannon are at the Children's Research Institute, St Petersburg, Florida 33701, USA.
Email: litmang@allkids.org
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