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Nature 459, 515-516 (28 May 2009) | doi:10.1038/459515a; Published online 27 May 2009

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Developmental biology: Transgenic primate offspring

Gerald Schatten1 & Shoukhrat Mitalipov2

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Genetically engineered monkeys carrying a foreign gene that is passed on to their offspring provide a potentially valuable bridge between mouse models of disease and treatment for human disorders.

The development of transgenic mice — in which foreign DNA is inserted into the mouse genome — meant that the functions of human genes could be studied rigorously in living animals rather than in cell culture. Developments in transgene technology, complemented by advances in reproductive cloning, have followed in other mammals, including rats, rabbits, pigs, cows, and even cats and dogs.

  1. Gerald Schatten is in the Departments of Obstetrics, Gynecology and Reproductive Sciences, and of Cell Biology, Physiology and Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
    Email: gschatten@pdc.magee.edu
  2. Shoukhrat Mitalipov is in the Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA.
    Email: mitalipo@ohsu.edu

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RESEARCH

Generation of transgenic non-human primates with germline transmission

Nature Article (28 May 2009)