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Nature 459, 334-335 (21 May 2009) | doi:10.1038/459334a; Published online 20 May 2009
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System Engineer (Mechanical)
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
University Full-Professor (W3, Tenure Track)
- University of Münster
- Munster 48149 Germany
Systems biology: When it is time to die
Philippe Bastiaens1
Abstract
Why do cells of the same population respond differently to external death-inducing stimuli? Individuality seems to originate from non-genetic differences in the levels and activation states of proteins.
Any cell biologist can tell you that individual cells from a clonal cell population respond differently to the same stimulus, some not responding at all. In such cases the percentage of responders is seen as a measure of the experimenter's control over parameters that affect the stimulus, such as uniformity of the cellular environment.
- Philippe Bastiaens is at the Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Email: philippe.bastiaens@mpi-dortmund.mpg.de
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RESEARCH
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosisNature Letters to Editor (21 May 2009)
