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GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis

Ryoji Fujiki, Toshihiro Chikanishi, Waka Hashiba, Hiroaki Ito, Ichiro Takada, Robert G. Roeder, Hirochika Kitagawa & Shigeaki Kato

Nature 459, 455-459(21 May 2009)

doi:10.1038/nature07954

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Figure 1

MLL5 acts as a co-activator of RARalpha.

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Figure 2

Purification of the HKMT-active MLL5 complex.

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Figure 3

MLL5 is a GlcNAcylation-dependent HKMT.

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Figure 4

GlcNAcylation of MLL5 facilitates RA-induced granulopoiesis.

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