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Cell biology

Arrest by ribosome

Impaired assembly of cells' protein-synthesis factories, the ribosomes, can cause cell-cycle arrest and disease. This finding emphasizes the close link between cell proliferation and ribosome formation.

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Figure 1: Ribosomal stress and p53 stabilization.

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Ferreira-Cerca, S., Hurt, E. Arrest by ribosome. Nature 459, 46–47 (2009). https://doi.org/10.1038/459046a

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