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Nature 458, 1075 (30 April 2009) | doi:10.1038/72421075b; Published online 29 April 2009

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Optical imaging is an indispensable tool for studying dynamic processes at high speeds and on micrometre scales. Unfortunately, conventional electronic cameras relying on charge-coupled devices (CCDs) cannot capture fast processes such as the dynamics of cell signalling with high sensitivity.

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