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Nature 458, 1118-1119 (30 April 2009) | doi:10.1038/4581118a; Published online 29 April 2009
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Cell biology: Another way to get rid of fat
Rudolf Zechner1 & Frank Madeo1
Abstract
When starved, cells resort to breaking down their assets — proteins, lipids and even whole organelles. An investigation of lipid metabolism indicates that one process — autophagy — targets all three cellular components.
Fatty acids are essential to all organisms — as substrates for energy production, as precursors of membrane lipids and as signalling molecules that control various cellular processes, including gene expression. They are stored as triglycerides in highly dynamic organelles called lipid droplets1 and, when necessary, are re-released by the process of lipolysis.
- Rudolf Zechner and Frank Madeo are at the Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria.
Email: rudolf.zechner@uni-graz.at
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