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Nature 458, 1056-1060 (4 March 2009) | doi:10.1038/nature07813;
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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary scale in eukaryotes that senses changes in the intracellular AMP/ATP ratio. Recent evidence indicated an important role for AMPK in the therapeutic benefits of metformin, thiazolidinediones and exercise, which form the cornerstones of the clinical management of type 2 diabetes and associated metabolic disorders.
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