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From the following article:
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Cantó, Zachary Gerhart-Hines, Jerome N. Feige, Marie Lagouge, Lilia Noriega, Jill C. Milne, Peter J. Elliott, Pere Puigserver & Johan Auwerx
Nature 458, 1056-1060(23 April 2009)
doi:10.1038/nature07813
Figure 1
Activation of AMPK triggers PGC-1
deacetylation in C2C12 myotubes and skeletal muscle.
Figure 2
SIRT1 mediates AMPK-induced PGC-1 deacetylation.
Figure 3
AICAR modulates PGC-1-dependent transcriptional activity, mitochondrial gene expression and oxygen consumption through SIRT1 and NAD+ metabolism.
Figure 4
The PGC-1 phosphorylation mutant is resistant to deacetylation.
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