Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 458, 840-841 (16 April 2009) | doi:10.1038/458840a; Published online 15 April 2009
Open Innovation Challenges
-
Methods to Analyze Consumer Emotions
The Seeker is looking for methods to analyze consumer emotions. This Challenge requires only a writ...
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
nature jobs
Copywriter
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
Executive- Purchase (Raw Material)- Coporate Office
- Rhydburg Pharmaceuticals
- Selaqui-Dehradun India
Biochemistry: Anchors away
Maria Paola Costi1 & Stefania Ferrari1
Abstract
Nature often adopts several approaches to crack the same problem. The finding that the mechanism of a crucial enzyme in certain disease-causing bacteria differs from that in mammals offers scope for drug discovery.
On page 919 of this issue, Koehn et al.1 propose that, in certain microorganisms, a previously unknown biochemical mechanism underpins the function of an enzyme that is essential to the microorganisms' survival. In mammals, the activity of this enzyme — thymidylate synthase — depends on an 'anchor' in its active site that binds covalently to the enzyme's substrate.
- Maria Paola Costi and Stefania Ferrari are in the Department of Pharmaceutical Science, Universitá degli Studi di Modena e Reggio Emilia, via Campi 183, Modena 41100, Italy.
Email: costimp@unimore.it
Email: stefania.ferrari@unimore.it
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in MiceJournal of Cerebral Blood Flow & Metabolism Original Article
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX geneNature Letters to Editor (16 Apr 2009)
See all 7 matches for Research
