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Nature 458, 766-770 (1 March 2009) | doi:10.1038/nature07863;
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30 Doctoral Stipends for Outstanding Young Researchers
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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
Transgenic expression of just four defined transcription factors (c-Myc, Klf4, Oct4 and Sox2) is sufficient to reprogram somatic cells to a pluripotent state. The resulting induced pluripotent stem (iPS) cells resemble embryonic stem cells in their properties and potential to differentiate into a spectrum of adult cell types.
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