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Nature 458, 585-586 (2 April 2009) | doi:10.1038/458585a; Published online 1 April 2009
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Neuroscience: AMPA receptors get 'pickled'
Alexander C. Jackson1 & Roger A. Nicoll1
Abstract
In mediating fast synaptic communication in the brain, AMPA receptors require TARP auxiliary proteins. It seems that another distinct class of proteins also bind to AMPA receptors and regulate their function.
It is now well established that ion channels are not solitary creatures, but often have an entourage of auxiliary proteins. Indeed, voltage-gated potassium, sodium and calcium channels form stable complexes with an assortment of both cytoplasmic and transmembrane proteins that profoundly affect their localization and function1.
- Alexander C. Jackson and Roger A. Nicoll are in the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA.
Email: nicoll@cmp.ucsf.edu
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